Late Stage Fluorination and its Applications to Drug Discovery

Explore new avenues towards late stage fluorination for the preparation and evaluation of

1) novel chemical entities (NCE) with fluorine or fluorine-containing groups and their application in drug discovery inclusive of fragment-based drug discovery (FBDD).

2) novel 18F-labeled radiochemical fragments, small molecules and biomolecules to support drug discovery and/or diagnostic studies as well as clinical programs.

3) a study of the fundamental metabolic profile and associated pharmacological profile of these new entities.